Upper Extremity Transplantation: Current Challenges and Future Prospects

Upper extremity transplantation has become a viable option over the past 26 years, promising sensory and motor function restoration, as well as enhanced quality of life. However, its feasibility is hindered by the inherent risks of lifelong immunosuppression and potential rejection, imposing a substantial financial strain on healthcare systems. 

This presentation addresses the multifaceted challenges of upper extremity transplantation, encompassing patient selection, quality of life impact, financial implications, functional outcomes, and immunosuppression-related complications. Precise patient selection is paramount, balancing potential benefits against immunosuppression risks. While upper extremity transplantation has shown to enhance quality of life, the extent of this improvement remains uncertain, necessitating further investigation for long-term effects. The financial burden is substantial, necessitating comprehensive economic evaluations. Functional outcomes are crucial, demanding optimal motor function and sensory feedback. Despite advancements in surgical techniques and rehabilitation, further research is imperative for optimizing outcomes. Immunosuppression-related complications, including infections and malignancies, pose significant concerns. Though new agents and regimens show promise, continual monitoring and management are essential.  

In summary, while upper extremity transplantation holds promise for improving quality of life and function, it entails significant risks and financial implications. Ongoing research is indispensable to refine patient selection, enhance functional outcomes, and mitigate complications.