Nerve entrapment syndromes, characterized by pain and dysfunction due to peripheral nerve compression, pose significant clinical challenges. Ultrasound (US)-guided injection has been regarded as a therapeutic tool for nerve entrapment. Utilizing high-resolution ultrasonography, clinicians can visualize the affected nerves and accurately administer therapeutic injectates directly to the site of entrapment. In this talk, techniques of US-guided perineural injection and evidence in various injectates will be reviewed. The presentation will also introduce applications of deep learning related to this issue. The talk aims to provide attendees with a comprehensive understanding of how US-guided injections enhance accuracy of diagnosis, and increase the success rates in managing nerve entrapment syndromes.